Sunday, March 18, 2012

Dieting - Not the answer for lifetime weight loss

Monterey surgeon says lifetime habit changes are key to weight-loss success

Dieting not the answer for successful long-term weight loss, surgeon says
By AMY E. WEST
Herald Staff Writer
Updated:   03/18/2012 12:03:04 AM PDT

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Dr. Mark Vierra is a board certified general surgeon and specializes in... (COURTESY OF CHOMP)
Bev Schiavoni wasn't the typical patient walking into the office of a weight-loss surgeon.
She wasn't focused on losing weight as much as removing 40 pounds of skin from dropping a great deal of weight through nutrition and exercise.
Yet for Dr. Mark Vierra, Schiavoni was just the kind of patient he needed. Vierra, who helps run the bariatric surgery center at Community Hospital of the Monterey Peninsula, wants patients to understand that proper nutrition and exercise are key to keeping the weight off.
"He was my hero, and I was his," Schiavoni said.
Nutrition became integral to Vierra's treatment for his patients when he started in metabolic surgery at Stanford University in 1990. Many of his patients had a "complicated nutritional background" from cancer treatments or injuries that left them unable to absorb nutrients. He helped them gain weight through nutritional counseling.
At the same time, he started fielding patients who wanted to lose weightthrough surgery.
"I learned a lot about weight control because of studying the extremes," he said.
One-third of Americans are obese, according to the Centers for Disease Control and Prevention. Though we spend significantly more on diet foods and diet programs than other countries, "We are getting fatter and fatter," he said.
The discrepancy indicates dieting is not the answer to weight control, Vierra said. "Very few people on any commercial diet program lose weight and keep it

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off."That includes contestants on the television program, "The Biggest Loser."
"I don't like the idea of the show because it emphasizes weight loss in a hurry," he said. One winner came to Vierra's seminar because he had regained the weight, he pointed out.

Multiple issues

Hormonal control during weight loss complicates issues. For instance, if a patient has an enormous amount of the stomach-producing hormone called ghrelin, they are typically obese. However, ghrelin, which is found to amplify the feeling of being hungry, can actually increase during dieting.
Most dieters also hit a plateau — once they reach a certain weight, it's an uphill battle to lose more.
"The more weight you lose, the harder it is to keep that weight off," Vierra said.
One study showed that six weeks after subjects lost 10 percent of their body weight, the body's metabolism slowed to burn 300 fewer calories. Without the extra weight, the body requires fewer calories and becomes more efficient at burning them.
This efficiency in metabolism is akin to switching from a gas-guzzler to a hybrid. Though the hybrid burns less fuel, there is much less power to help climb the hill (i.e., shave off additional pounds).
To get past that plateau, people must not only cut their calorie intake far more than just 300 calories, but also continually ramp up their exercise program — a discouraging prospect for many dieters.
Kevin Hall, an obesity researcher from the National Institute of Diabetes and Digestive and Kidney Diseases, illustrates this metabolic dilemma through mathematics. He created a model based on years of controlled feeding studies to simulate a more realistic picture of what to expect when changing one's diet. He published his research in The Lancet in August 2011.
"We've known for decades that if you cut the calories in someone's diet, their metabolism slows down," Hall said.
The simulation takes into account how metabolism adapts during weight loss. By plugging in sex, age, weight, height, and answering questions about physical activity, the model predicts what realistic changes of diet or exercise are needed to achieve the goal weight. And more importantly what to do permanently to maintain that weight loss," Hall said.
He notes that people are successful in short-term weight loss (most of it as water weight), but fail to maintain that loss over time.
His model also upsets the dieting rule of thumb that even his own institution prescribes, which states a daily 500-calorie restriction equates to losing a pound a week, and that this type of loss should continue. Not only does this approach overestimate weight loss, but it fails to address how to sustain that weight. Weight loss is not linear, he explains, but gradually slows over time. With variations in people's activity levels, percentage and location of body fat, initial weight, etc. .. it can get complicated, Hall said.
Instead of the 3,500 calories per pound, one can expect to lose half the target weight in a year, and achieve the goal weight within three years.
Though the simulator is meant for researchers and dietitians, Hall's goal is to develop it into a more public-friendly tool that translates the predicted calories into actual foods. In the meantime, it gives people an idea of whether their weight-loss goals are reasonable.

Changing environments

Vierra notes the success of his patients who lost weight without surgery — they changed their environment, and left a lifestyle that perpetuated unhealthy habits.
Making critical life changes comes not only with restructuring our environment, such as changing jobs, he said, but being aware of the ubiquitous processed food we consume that has a "seductive secret sauce of salt, fat and sugar."
Schiavoni did just that.
Weighing 440 pounds in her early 50s, she faced the prospect of dying. And that woke her up.
"I wanted to see my grandkids grow up," she said.
Now at 70 and 250 pounds lighter, she attributes this loss to a change in lifestyle, food, and getting a golden retriever.
Casey, her walking partner of 13 years, accompanied Schiavoni two or three miles each day — and didn't allow her to skip walking him.
" I walked real early in the morning, because I am lazy about exercise. If I don't do it then I will find a 101 excuses why not to do it," she said. "If you just get out there and do it, then it's out of the way for the day."
Though her dog passed away last year, she continues to walk among the early morning exercisers who tell her, "You don't look right without your dog."
With the encouragement of Weight Watchers and their recipes, she learned to alter the amount of food she ate, never ate past 7 p.m., removed cake, candy and ice cream from her diet, switched to unfried fish and chicken, and consumed more fresh fruit and vegetables. Once she began taking care of herself, she felt better and even started shopping — something that she hadn't done for many years.
Schiavoni discussed bariatric surgery at one point with Vierra, though she noticed that those who underwent the procedure put the weight back on. It may jump-start a 100- to 200-pound loss, but if they don't alter their lifestyle to do what Schiavoni is doing, it doesn't matter, she said. "I know Dr. Vierra really stresses it, but I don't think people really hear it."
What Schiavoni empathizes with most is that her brain and the brain of those who are overweight respond very differently to food. "Food is a serious addiction. We have to eat to survive," she said.

Fast food dilema

For Vierra, convincing people about the ins and outs of fast food frustrates him the most.
"Making lunch or grabbing an apple and yogurt is so much faster, so much cheaper and so much healthier than going through a drive-through," he said.
Though many families claim to not have time or money to eat healthy, Vierra said it only takes some advance planning and simple cooking. Learning to make a healthy alternative to fast food, such as a lentil stew for $20, can feed a family for several meals.
Like his favorite food author, Michael Pollan, whose books Vierra suggests his patients read, Vierra pushes for eating local, nutritious whole foods. He, too, would like to see subsidies decrease for crops that are of little nutritional value, such as corn.
"We pay more attention to how we feed our pets than we do ourselves," Vierra said. "If there was Coca-Cola and Captain Crunch for the dog, you'd call the SPCA, but we think it's perfectly fine to feed our children."

Vierra is a board certified general surgeon and specializes in bariatric surgery. His office is in Ryan Ranch in Monterey and he has been a member of Community Hospital's medical staff since 2001.

Weight-loss talk

For people who are considering a surgical approach to weight loss and improved health, Dr. Mark Vierra offers a free monthly lecture on the biological basis for obesity, strategies for weight loss and surgical options.

When: 7 to 8:30 p.m. the first Thursday of each month
Where: Main conference room at Community Hospital of the Monterey Peninsula, 23625 Holman Highway, Monterey
Information: 649-0808

Friday, March 16, 2012

Sex-Deprived Male Fruit Flies Turn to Alcohol, Research Shows


Male fruit flies become barflies when rejected by females, choosing alcohol-spiked food more often than their successful brothers in a study that suggests it may be due to a brain chemical also found in humans.
The spurned flies had lower levels of a molecule in their brains called neuropeptide F than the males who were allowed to mate, according to findings published today in the journal Science. Neuropeptide Y, the version found in humans, has been tied to addiction and mental illness, saidUlrike Heberlein, one of the researchers.
This is a picture of Oriental Fruit Flies. Photographer: Jeff Lotz. Bloomberg News.
The molecule may begin to explain how experience and environment shape human addictions, said Heberlein. About half of a person’s risk of addiction is genetic, and environment is known to play a role. The experiment may help explain the biological triggers that affect certain behavior or cravings and could help research into treatments for addiction.
“We wanted to really find a molecular mechanism that links experiences to drug-related behavior,” said Heberlein, who is a neuroscientist at the University of CaliforniaSan Francisco, in a telephone interview. “We are really hoping that this will encourage those working with mice and rats and humans to look at what happens to this neuropeptide in psychiatric conditions.”
Male flies that mated were less likely to drink the alcohol solution than either virgin or rebuffed ones, and had higher levels of neuropeptide F in their brains, the research showed.

Mating Sessions

In the experiment, some flies were spurned by already-mated females for one hour a day, three times a day, for four days. The successful flies had six-hour mating sessions with multiple virgin females for four days. They were then allowed to choose food that was either plain or spiked with a 15 percent alcohol solution.
Another experiment was done to see whether sexual deprivation or social isolation was the main difference between the groups. A set of flies, consisting of both virgin and mated males, were housed in a group. The virgin males showed a higher preference for alcohol.
Next, the researchers checked to see whether it was lack of sex or the actual rejection that made the flies likelier to drink. For that test, researchers put virgin males in with decapitated females, so they would experience neither rejection nor copulation. They also preferred alcohol more than mated flies, suggesting that a lack of sex rather than rejection was the major factor in their alcohol preference.
The researchers then lowered the amount of neuropeptide F in the brains of mated flies and found that they acted as though they had been rejected, drinking more. Conversely, flies that had been spurned whose neuropeptide F was increased boozed less.
“What we did, in order to establish a causal relationship, was manipulated the system,” Heberlein said. “We were able to prove it in both directions, so that’s strong evidence of causality.”
Levels of neuropeptide Y are lower in people who are depressed and have post-traumatic stress disorder. It’s found all over the brain and may have roles in eating and sleeping, as well as addiction and anxiety.
To contact the reporter on this story: Elizabeth Lopatto in New York at elopatto@bloomberg.net.
To contact the editor responsible for this story: Reg Gale at rgale5@bloomberg.net.

Wednesday, February 29, 2012

Random Note

New York Public Library Buys Timothy Leary’s Papers

Librado Romero/The New York Times
Files from Timothy Leary's archive. More Photos »
When the Harvard psychologist and psychedelic explorer Timothy Leary first met the Beat poet Allen Ginsberg in 1960, he welcomed Ginsberg’s participation in the drug experiments he was conducting at the university.
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“The first time I took psilocybin — 10 pills — was in the fireside social setting in Cambridge,” Ginsberg wrote in a blow-by-blow description of his experience taking synthesized hallucinogenic mushrooms at Leary’s stately home. At one point Ginsberg, naked and nauseated, began to feel scared, but then “Professor Leary came into my room, looked in my eyes and said I was a great man.”
Ginsberg’s “session record,” composed for Leary’s research, was in one of the 335 boxes of papers, videotapes, photographs and more that the New York Public Library is planning to announce that it has purchased from the Leary estate. The material documents the evolution of the tweedy middle-aged academic into a drug guru, international outlaw, gubernatorial candidate, computer software designer and progenitor of the Me Decade’s self-absorbed interest in self-help.
The archive will not be available to the public or scholars for 18 to 24 months, as the library organizes the papers. A preview of the collection, however, reveals a rich record not only of Leary’s tumultuous life but also of the lives of many significant cultural figures in the ’60, ’70s and ’80s.
Robert Greenfield, who combed through the archive when it was kept in California, for his 2007 biography of Leary, said: “It is a unique firsthand archive of the 1960s. Leary was at the epicenter of what was going on back then, and some of the stuff in there is extraordinary.”
Leary, who died in 1996, coined the phrase “Turn on, tune in, drop out” and was labeled by Richard M. Nixon as “the most dangerous man in America.” He was present in Zelig-like fashion at some of the era’s epochal events. Thousands of letters and papers from Ginsberg, Aldous Huxley, William Burroughs, Jack Kerouac, Ken Kesey, Charles Mingus, Maynard Ferguson, Arthur Koestler, G. Gordon Liddy and even Cary Grant — an enthusiastic LSD user — are in the boxes.
“How about contributing to my next prose masterpiece by sending me (as you sent Burroughs) a bottle of SM pills,” Kerouac wrote Leary, referring to psilocybin. “Allen said I could knock off a daily chapter with 2 SMs and be done with a whole novel in a month.”
Denis Berry, a trustee of the Leary estate, said that the library paid $900,000 for the collection, some of which is being donated back to finance the processing of the material. The rest will pay the estate’s caretakers and then be divided among Leary’s surviving children and grandchildren. Ms. Berry said the estate had been looking for a buyer for the archive for years.
William Stingone, curator of manuscripts at the library, predicted that the collection would help researchers get beyond the “myth making” around ’60s figures. “Hopefully we’ll be able to get to some of the truth of it here,” he said.
The complete documentation of Leary’s early experiments with psychotropic drugs, for example, can allow scholars to assess the importance of that work in light of current clinical research on LSD, Mr. Stingone said. Ms. Berry called the Harvard data “the missing link.”
The meeting between Ginsberg and Leary marked an anchor point in the history of the 1960s drug-soaked counterculture. Leary, the credentialed purveyor of hallucinatory drugs, was suddenly invited into the center of the artistic, social and sexual avant-garde. It was Ginsberg who helped convince Leary that he should bring the psychedelic revolution to the masses, rather than keep it among an elite group. Filling out one of Leary’s research questionnaires in May 1962 the poet Charles Olson wrote that psilocybin “creates the love feast,” and “should be available to anyone.”
This article has been revised to reflect the following correction:
Correction: June 17, 2011
Because of an editing error, an article on Thursday about the New York Public Library’s acquisition of the archive of Timothy Leary misstated the amount the library paid the Leary estate for the collection. It was $900,000, not “$900,00.”

Tuesday, February 14, 2012

Thursday, February 2, 2012

Sunday, January 22, 2012

January 22, 2012

It occurred to me that a Romney and Christie ticket will be how it works out.